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浙江第三代试管婴儿:Cell:PI3K与癌细胞之间的奥

2018-05-14 本文已影响 150人  未知

  Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

  Hai Hu, Ashish Juvekar, Costas A. Lyssiotis14, Evan C. Lien, John G. Albeck15, Doogie Oh, Gopal Varma, Yin Pun Hung, Soumya Ullas, Josh Lauring, Pankaj Seth, Mark R. Lundquist, Dean R. Tolan, Aaron K. Grant, Daniel J. Needleman, John M. Asara, Lewis C. Cantley13, Gerburg M. Wulf

  The phosphoinositide 3-kinase (PI3K) pathway regulates multiple steps in glucose metabolism and also cytoskeletal functions, such as cell movement and attachment. Here, we show that PI3K directly coordinates glycolysis with cytoskeletal dynamics in an AKT-independent manner. Growth factors or insulin stimulate the PI3K-dependent activation of Rac, leading to disruption of the actin cytoskeleton, 浙江第三代试管婴儿:Cell:PI3K与癌细胞之间的奥 release of filamentous actin-bound aldolase A, and an increase in aldolase activity. Consistently, PI3K inhibitors, but not AKT, SGK, or mTOR inhibitors, cause a significant decrease in glycolysis at the step catalyzed by aldolase, while activating PIK3CA mutations have the opposite effect. These results point toward a master regulatory function of PI3K that integrates an epithelial cell’s metabolism and its form, shape, and function, coordinating glycolysis with the energy-intensive 浙江第三代试管婴儿:Cell:PI3K与癌细胞之间的奥 dynamics of actin remodeling.


我想问问无锡妇幼保健医院能做试管婴儿吗?大概要多少钱?
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